Scientists have discovered the first stage of a ‘DNA repair engine' that reverses the beneficial effects of chemotherapy.
The study, conducted by Cancer Research UK, discovered a DNA pathway that is vital to the repair of cancer cells after they have been treated by chemotherapy. It is hoped this could result in new drugs being developed to increase the effectiveness of treatment by targeting this pathway and ‘switching off' the repair. Until now a lack of structural information on the pathway has hindered a complete molecular understanding of associated diseases, including cancer, and made it more difficult to develop effective treatments to block it. Dr Helen Walden, lead investigator at Cancer Rese...
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